Fate to make love with male (4)
I believe the answer is:
doom
'fate' is the definition.
(doom is a kind of fate)
'make love with male' is the wordplay.
'make' becomes 'do' (synonyms).
'love' becomes 'o' (love means zero in tennis).
'with' says to put letters next to each other.
'male' becomes 'm' (common abbreviation).
'do'+'o'+'m'='DOOM'
'to' acts as a link.
(Other definitions for doom that I've seen before include "__ and gloom" , "Bad destiny" , "Day of reckoning" , "Terrible fate; death" , "Condemn (to certain death?)" .)