Filling it may be a piece of cake (5)
I believe the answer is:
mouth
'piece of cake' is the definition.
'mouth' can be an answer for 'piece' (mouth is a kind of piece). I'm not sure about the 'of cake' bit.
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for mouth that I've seen before include "Gob" , "Opening; say" , "trap" , "River part - conversation opener?" , "Opening of a bay" .)