First man... a motherly female? (4)
I believe the answer is:
adam
'first man' is the definition.
(I've seen this before)
'a motherly female?' is the wordplay.
'motherly female?' becomes 'dam' (term for a female animal that has given birth).
'a'+'dam'='ADAM'
(Other definitions for adam that I've seen before include "first in the race?" , "man expelled from garden" , "Eve's partner" , "Robert ..., ... Clayton" , "One of our common ancestors?" .)