Girl out of action by wrongdoings (8)
I believe the answer is:
misdeeds
'wrongdoings' is the definition.
(misdeed is a kind of wrongdoing)
'girl out of action' is the wordplay.
'girl' becomes 'miss' (synonyms).
'out of' indicates putting letters inside.
'action' becomes 'deed' (deed is a kind of action).
'miss' going around 'deed' is 'MISDEEDS'.
'by' acts as a link.
(Other definitions for misdeeds that I've seen before include "Wrongdoing" , "Bad acts" , "Wrongful actions" .)