Handle danger hospital ignored (5)
I believe the answer is:
treat
'handle' is the definition.
(I know that handle can be written as treat)
'danger hospital ignored' is the wordplay.
'danger' becomes 'threat' (threat can mean a danger or risk).
'hospital' becomes 'H' (abbreviation for hospital on maps).
'ignored' indicates named letters should be taken away.
'threat' with 'h' taken out is 'TREAT'.
(Other definitions for treat that I've seen before include "Stand a drink" , "Attend to; surprise gift" , "Source of gratification" , "Doctor, manage" , "Enjoyable surprise gift" .)