Highly-strung (5)
(Other definitions for wired that I've seen before include "Bugged" , "Using cables; tense, edgy" , "Equipped for electrical connection" , "Equipped for electricity" , "In a tense state" .)
(Other definitions for nervy that I've seen before include "Highly-strung" , "Easily agitated, tense" , "Excitable" , "close to the edge?" , "Anxious, jumpy" .)