Hot fish for despicable people (5)
I believe the answer is:
heels
'despicable people' is the definition.
(I've seen this before)
'hot fish' is the wordplay.
'hot' becomes 'h' (abbreviation eg on taps).
'fish' becomes 'eels' (eel is a type of fish).
'h'+'eels'='HEELS'
'for' is the link.
(Other definitions for heels that I've seen before include "Parts of body; tilts" , "Leans, lists or tilts" , "Parts of shoes" , "Take to them and run away" , "Dastardly types" .)