House makes Virginia sick inside (5)
I believe the answer is:
villa
'house' is the definition.
(villa is a kind of house)
'virginia sick inside' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'sick' becomes 'ill' (synonyms).
'inside' means one lot of letters goes inside another.
'va' enclosing 'ill' is 'VILLA'.
'makes' is the link.
(Other definitions for villa that I've seen before include "Detached house" , "Aston ..., English Premier League club" , "Country house in Italy or France" , "Country house (in Aston?)" , "SECOND PART OF 8" .)