Insecure United fans agitated with point (6)
I believe the answer is:
unsafe
'insecure' is the definition.
('unsafe' is associated in meaning with 'insecure')
'united fans agitated with point' is the wordplay.
'united' becomes 'u'.
'agitated with' indicates an anagram.
'point' becomes 'e' (E is an example).
'fans' mixed up with 'e' gives 'nsafe'.
'u'+'nsafe'='UNSAFE'
(Other definitions for unsafe that I've seen before include "Dangerous - legally without basis" , "Not reliable, dangerous - perhaps a legal conviction" , "giving no protection" , "Risky - inadequately evidenced" , "Unreliable" .)