Lame inspector's guided by Jack (8)
I believe the answer is:
disabled
'lame' is the definition.
(lame can unable to walk normally)
'inspector's guided by jack' is the wordplay.
'inspector's' becomes 'di's' (detective inspector's).
'guided' becomes 'led' (similar in meaning).
'by' is a charade indicator (letters next to each other).
'jack' becomes 'ab' (both can mean a sailor).
'led' put after 'ab' is 'abled'.
'dis'+'abled'='DISABLED'
(Other definitions for disabled that I've seen before include "Not able to work" , "Incapacitated" , "Having a physical incapacity caused by injury or disease" , "Put out of action" .)