Live comfortably after heading for disaster (5)
I believe the answer is:
dwell
'live' is the definition.
(to live/dwell somewhere)
'comfortably after heading for disaster' is the wordplay.
'comfortably' becomes 'well' (synonyms).
'after' means one lot of letters go next to another.
'heading for' suggests taking the first letters.
The first letter of 'disaster' is 'd'.
'well' after 'd' is 'DWELL'.
(Other definitions for dwell that I've seen before include "Reside - linger" , "Hang out" , "Lodge" , "Live (in a place)" , "Abide, reside" .)