Live to flourish, losing nothing (5)
I believe the answer is:
dwell
'live' is the definition.
(to live/dwell somewhere)
'to flourish losing nothing' is the wordplay.
'to flourish' becomes 'dowell' (I've seen this before).
'losing' indicates named letters should be taken away.
'nothing' becomes 'O' (looks like zero - 0).
'dowell' with 'o' taken away is 'DWELL'.
(Other definitions for dwell that I've seen before include "Exist (within)" , "Focus attention (on)" , "Abide, reside" , "Think moodily (on something)" , "Live (in a place)" .)