Lose hope as pride is destroyed (7)
I believe the answer is:
despair
'lose hope' is the definition.
(synonyms)
'as pride is destroyed' is the wordplay.
'is destroyed' indicates an anagram.
'as'+'pride'='aspride'
'aspride' anagrammed gives 'DESPAIR'.
(Other definitions for despair that I've seen before include "Abandon hope" , "Lose heart" , "gloom" , "The feeling that nothing will turn out well" , "Opposite of 10" .)