Lose hope as pride shattered (7)
I believe the answer is:
despair
'lose hope' is the definition.
(synonyms)
'as pride shattered' is the wordplay.
'shattered' indicates anagramming the letters.
'as'+'pride'='aspride'
'aspride' is an anagram of 'DESPAIR'.
(Other definitions for despair that I've seen before include "Total loss of hope" , "An unhappy state" , "Despond" , "The feeling that nothing will turn out well" , "Be without hope" .)