Lower (6)
'lower' is the definition.
(as in nether regions)
This is the entire clue.
(Other definitions for nether that I've seen before include "Subordinate" , "These garments are for the bottom half" , "Located below" , "Situated below" , "North European country" .)
'lower' is the definition.
(depressing is a kind of lowering)
This is all the clue.
(Other definitions for depress that I've seen before include "Make dejected" , "Make sad or gloomy" , "Make miserable or lower" , "Bring down" , "Cause to feel dispirited" .)