Made an effort though tired out (5)
I believe the answer is:
tried
'made an effort' is the definition.
(I've seen this before)
'tired out' is the wordplay.
'out' indicates anagramming the letters (out can mean wrong or inaccurate).
'tired' with letters rearranged gives 'TRIED'.
'though' acts as a link.
(Other definitions for tried that I've seen before include "Sampled" , "Essayed" , "checked out" , "Attempted" , "Had a crack" .)