Mary, perhaps popular after overthrow of former Prince Regent? (6)

I believe the answer is:

virgin

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'mary' is the definition.
(synonyms)

'popular after overthrow of former prince regent?' is the wordplay.
I cannot really see how this works, but
'popular' could be 'in' ('in' can mean trendy) and 'in' is present in the answer.
This explanation may well be incorrect...

'perhaps' acts as a link.

Can you help me to learn more?

(Other definitions for virgin that I've seen before include "Not yet used" , "Pure" , "Vestal" , "A person who has never had sex" , "Unspoilt" .)

I've seen this clue in The Independent.

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