Misery and gladness initially emerge (5)
I believe the answer is:
gloom
'misery' is the definition.
(I've seen this before)
'gladness initially emerge' is the wordplay.
'initially' indicates taking the first letters.
'emerge' becomes 'loom' (I've seen this in another clue).
The first letter of 'gladness' is 'g'.
'g'+'loom'='GLOOM'
'and' acts as a link.
(Other definitions for gloom that I've seen before include "Murk" , "Murkiness" , "Melancholy state" , "Depression and melancholy" , "Darkness; depression" .)