Mrs Reagan in French city (5)
I believe the answer is:
nancy
'french city' is the definition.
(city in France)
'mrs reagan' is the wordplay.
'mrs' becomes 'Nan'.
'reagan' becomes 'cy' (I can't justify this - if you can you should give a lot more credence to this answer).
'nan'+'cy'='NANCY'
'in' acts as a link.
Can you help me to learn more?
(Other definitions for nancy that I've seen before include "Dickensian murder victim - city in northeast France" , "in Oliver?" , "Girl's name; NE French city" , "Girl; French city" , "Bill Sikes's girl (Dickens)" .)