Native guide's in no trouble (10)
I believe the answer is:
indigenous
'native' is the definition.
('indigenous' can be similar in meaning to 'native')
'guide's in no trouble' is the wordplay.
'trouble' is an anagram indicator.
'guides'+'in'+'no'='guidesinno'
'guidesinno' is an anagram of 'INDIGENOUS'.
(Another definition for indigenous that I've seen is " Native".)
I've seen this clue in The Telegraph.
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