Sad after race, gradually deteriorate (3,4)
I believe the answer is:
run down
'deteriorate' is the definition.
(I know that run down is a more specific form of the action fatigue)
'sad after race gradually' is the wordplay.
'sad' becomes 'down' (down can mean sad or unhappy).
'after' is a charade indicator (letters next to each other).
'race gradually' becomes 'run' (synonyms. I am not sure about the 'gradually' bit.).
'down' after 'run' is 'RUN-DOWN'.
Can you help me to learn more?
(Other definitions for run down that I've seen before include "slate" , "After search" , "Songbird" , "not very well" , "Hit (pedestrian) (3,4); debilitated" .)