Sadly (4)

I think it could be either:

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5,2,3

alas

'sadly' is the definition.
('alas' is used to express regret)

This is all the clue.

(Other definitions for alas that I've seen before include "Sad to say!" , "Cry of woe" , "Proper, respectable" , "Archaic exclamation of sorrow or regret" , "Regretfully!" .)

I've seen this clue in the USA Today, the Sydney Morning Herald, the Universal, the Evening Standard and The Telegraph.

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