She takes me out for a change of air (5)
I believe the answer is:
marie
'she' is the definition.
'me out for a change of air' is the wordplay.
'out' means one lot of letters goes inside another.
'for a change of' indicates anagramming the letters (I've seen 'for a change' mean this).
'air' with letters rearranged gives 'ari'.
'me' placed around 'ari' is 'MARIE'.
'takes' is the link.
(Other definitions for marie that I've seen before include "- Lloyd, English music- hall entertainer" , "French queen, d.1793" , "-- Antoinette" , "girl" , "-- Curie, scientist" .)