Single ladies to dance (8)
I believe the answer is:
isolated
'single' is the definition.
(I've seen this before)
'ladies to dance' is the wordplay.
'dance' is an anagram indicator.
'ladies'+'to'='ladiesto'
'ladiesto' anagrammed gives 'ISOLATED'.
(Other definitions for isolated that I've seen before include "kept separate" , "Idols ate (anag.)" , "Segregated" , "Remote, set apart" , "(Left) on one's own" .)