Skin problem developed from cane (4)
I believe the answer is:
acne
'skin problem' is the definition.
(I've seen this before)
'developed from cane' is the wordplay.
'developed from' indicates an anagram.
'cane' with letters rearranged gives 'ACNE'.
(Other definitions for acne that I've seen before include "Spotty skin condition" , "Cane for the teenager?" , "Face problems" , "Pimply skin condition of adolescence" , "Teenage spots" .)