So sad somehow imbibing last of Portuguese port (6)
I believe the answer is:
odessa
'port' is the definition.
(Odessa is a Ukrainian port)
'so sad somehow imbibing last of portuguese' is the wordplay.
'somehow' indicates anagramming the letters.
'imbibing' is an insertion indicator (imbibe can mean to drink or absorb).
'last of' suggests the final letters.
The final letter of 'portuguese' is 'e'.
'so'+'sad'='sosad'
'sosad' with letters rearranged gives 'odssa'.
'odssa' placed around 'e' is 'ODESSA'.
(Other definitions for odessa that I've seen before include "Port city of Ukraine" , "Ukrainian naval base" , "Port city on the Black Sea" , "Do seas come into Ukrainian city?" , "Ukrainian location" .)