Spot around right leg, at the end of the twilled fabric (5)
I believe the answer is:
serge
'the twilled fabric' is the definition.
(I've seen this before)
'spot around right leg at the end' is the wordplay.
'spot' becomes 'see' (I've seen this before).
'around' is an insertion indicator.
'right' becomes 'R' (common abbreviation).
'at the end' says to take the final letters.
The last letter of 'leg' is 'g'.
'r'+'g'='rg'
'see' placed around 'rg' is 'SERGE'.
'of' is the link.
(Other definitions for serge that I've seen before include "Material to suit" , "Frenchman" , "Twilled fabric; name" , "Stuff" , "A twill fabric" .)