State origins of open hostility in Oxford (4)
I believe the answer is:
ohio
'state' is the definition.
(I know that Ohio is a American state)
'origins of open hostility in oxford' is the wordplay.
'origins of' suggests taking the first letters.
The first letters of 'open hostility in oxford' is 'OHIO'.
(Other definitions for ohio that I've seen before include "Midwest US state" , "State of east central US" , "American state, capital Columbus" , "E. central US state" , "Midwestern US state and river" .)