Suppose one includes a mathematical symbol (5)
I believe the answer is:
opine
'suppose' is the definition.
(I know that suppose can be written as opine)
'one includes a mathematical symbol' is the wordplay.
'includes' indicates putting letters inside.
'a mathematical symbol' becomes 'pi' (pi is a kind of symbol. I am not sure about the 'mathematical' bit.).
'one' enclosing 'pi' is 'OPINE'.
Can you help me to learn more?
(Other definitions for opine that I've seen before include "Conjecture" , "Suppose" , "State one's held view" , "State as one's belief" , "State as one's opinion" .)