Swear there's nothing out of the way (5)
I believe the answer is:
curse
'swear' is the definition.
(I know that swear can be written as curse)
'nothing out of the way' is the wordplay.
'nothing' becomes 'cure' (I am not sure about this - if you are sure you should believe this answer much more).
'out of' means one lot of letters goes inside another (some letters on the outside of others).
'the way' becomes 's' (Compass direction - South).
'cure' placed around 's' is 'CURSE'.
'there's' acts as a link.
Can you help me to learn more?
(Other definitions for curse that I've seen before include "Excommunication" , "Oath or a call for evil to come upon person" , "Malediction or expletive" , "Invocation of evil; swear" , "Wish harm on" .)