The game's up! Edward's confined to school (5)
I believe the answer is:
gated
'confined to school' is the definition.
(I've seen this before)
'the game's up edward's' is the wordplay.
'the game' becomes 'tag' (tag is a kind of game**).
'up' is a reversal indicator (in down clue: letters go upwards).
'edward' becomes 'ed'.
'tag' backwards is 'gat'.
'gat'+'ed'='GATED'
(Other definitions for gated that I've seen before include "Under curfew" , "kept in school" , "Forbidden to leave college" , "deprived of liberty for a while" , "temporarily confined" .)