Times covers wise guys set up for crime (6)
I believe the answer is:
bigamy
'crime' is the definition.
(bigamy is a kind of crime)
'times covers wise guys set up' is the wordplay.
'times' becomes 'by' (both can mean 'multiplied by').
'covers' means one lot of letters goes inside another.
'wise guys' becomes 'magi' (I've seen this in another clue).
'set up' is a reversal indicator (in a down clue, letters go up).
'magi' written backwards gives 'igam'.
'by' going around 'igam' is 'BIGAMY'.
'for' is the link.
(Other definitions for bigamy that I've seen before include "Having more than one spouse, illegally" , "Marrying one person while married to another" , "Instance of having two spouses" , "overmatiness" , "Illegal marriage to more than one person" .)