You can do what you like with it (6)
I believe the answer is:
relish
'you can do what you' is the definition.
I can't tell whether this definition defines the answer.
'like with it' is the wordplay.
'like' becomes 'ish' ('ish' can be similar in meaning to 'like').
'with' means one lot of letters go next to another.
'it' becomes 'rel' (I can't explain this - if you can you should believe this answer much more).
'ish' put after 'rel' is 'RELISH'.
Can you help me to learn more?
(Other definitions for relish that I've seen before include "Savour; chutney" , "savoury preserve" , "Look forward to" , "smack" , "Sauce to savour?" .)