Deeply sad tendency in an audience (12)
I believe the answer is:
heartrending
'deeply sad' is the definition.
I can't tell whether this defines the answer.
'tendency in an audience' is the wordplay.
'tendency' becomes 'trend' (synonyms).
'in' indicates putting letters inside.
'an audience' becomes 'hearing' ('hearing' can be a synonym of 'audience').
'trend' going within 'hearing' is 'HEARTRENDING'.
Can you help me to learn more?
(Other definitions for heartrending that I've seen before include "causing great sadness" , "Distressing" , "Tragic" , "Agonising" .)