Different guides then bless you! (10)
I believe the answer is:
gesundheit
'bless you' is the definition.
I can't tell whether this defines the answer.
'different guides then' is the wordplay.
'different' is an anagram indicator (letters placed in a different order).
'guides'+'then'='guidesthen'
'guidesthen' is an anagram of 'GESUNDHEIT'.
Can you help me to learn more?
(Other definitions for gesundheit that I've seen before include "bless you!" , "Saxon good health" .)